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The hormone, ACTH, stimulates the adrenal gland to secrete large amounts of cortisol into the bloodstream. This action causes a euphoric response in the brain as well as a potent anti-inflammatory effect at the tissue level.
Adrenocorticotropic hormone (ACTH), also known as corticotrophin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic pituitary adrenal axis and is often produced in response to biological. Its principal effects are increased production and release of corticosteroids.
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ACTH stimulates secretion of the glucocorticoid steroid hormones from the adrenal cortex cells, especially in the zona fasciculata of adrenal glands.
It acts by binding to cell surface ACTH receptors, which are located primarily on the adrenocortical cells of the adrenal cortex.
The ACTH receptor is a seven membrane spanning G protein- oupled receptor. Upon ligand binding, the receptor undergoes conformation changes to stimulate the enzyme adenylyl cyclase, which does lead to an increase in intracellular cAMP and subsequent activation of protein kinase.
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ACTH influences steroid hormone secretion by both rapid short term mechanisms that takes place within minutes and slower long term actions.
The rapid actions of ACTH include stimulation of cholesterol delivery to the mitochondria where P450scc enzyme is located.
P450scc catalyzes the first step of steroidogenesis and is cleavage of the side chain of cholesterol. ACTH also stimulates lipoprotein uptake into the cortical cells.
This increases the bioavailability of cholesterol in cells of the adrenal cortex.
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