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Buy Pentosan Gold online is a sterile solution formulated as an aid in the treatment of noninfectious inflammatory joint disease in horses.
What is Pentosan Gold?
Buy Pentosan Gold and Pentosan Platinum Pentosan Platinum is a sterile solution formulated as an aid in the treatment of noninfectious inflammatory joint disease in horses.
It is indicated as an aid in the treatment of non-infectious, inflammatory joint disease in the horse.
Clinical applications include the following conditions: osteoarthritis, osteochondritis dissecans (OCD), traumatic joint and periarticular inflammation.
If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.
It is used to treat pain/ discomfort from a certain bladder disorder (interstitial cystitis).
It may work by forming a layer on the bladder wall and protecting it from harmful/irritating substances in the urine.
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– Inhibition of neutrophil migration into the joint.
– Stimulation of hyaluronic acid synthesis by synovial fibroblasts, resulting in increased volume and viscosity of synovial fluid.
– Stimulation of proteoglycan synthesis by chondrocytes.
– Fibrinolytic activity, resulting in improved circulation to subchondral bone and periarticular structures.
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Pentosan Platinum actively reverses the effects of osteoarthritis in the joints via a series of actions including:
1. Stimulating Chondrocyte Metabolism: Results in increased production of proteoglycans and healthy cartilage matrix.
PPS stimulates synovial fibroblasts and produces an increased amount of high molecular weight hyaluronic acid which results in an increased production of normally viscous joint fluid.
Improving the fluid volume and consistency results in more effective joint lubrication and also stabilisation, which limits further cartilage damage.
2. Anti-inflammatory Activity: PPS has an inhibitory action on all mediators of the arachidonic acid cascade.
PPS also inhibits the lysosomal catabolic enzymes histamine, hyaluronidase, cathepsin B, and polymorphonuclear elastase. PPS exerts a specific inhibitory effect on mediators implicated in the degradation of cartilage matrix components, preserving the cartilage and thus preventing the release of the highly inflammatory mediators, which relieves pain and inflammation.
Fibrinolysis and Lipolysis: PPS is strongly fibrinolytic, stimulating the release of plasminogen activator and promotes the dissolution of thrombi and fibrin deposits in synovial tissues and subchondral blood vessels. PPS also mobilizes lipids and cholesterol in synovial and subchondral blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals.
These effects combine to increase the pre-fusion to the joint, which stimulates cartilage healing and repair.
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